Methyl 3,3,3-trifluoro-2-oxopropanoate → HCID 44138675, compound

HRID 424925Notes

Reaction equation

[CH:1]([C:4]1[CH:9]=[CH:8][C:7]([N:10]2[C:14](=[O:15])[CH:13]=[C:12]([CH3:16])[NH:11]2)=[CH:6][CH:5]=1)([CH3:3])[CH3:2].[F:17][C:18]([F:26])([F:25])[C:19](=[O:24])[C:20]([O:22][CH3:23])=[O:21]>C(Cl)(Cl)Cl>[CH3:23][O:22][C:20](=[O:21])[C:19]([OH:24])([C:18]([F:26])([F:25])[F:17])[C:13]1[C:14](=[O:15])[N:10]([C:7]2[CH:6]=[CH:5][C:4]([CH:1]([CH3:3])[CH3:2])=[CH:9][CH:8]=2)[NH:11][C:12]=1[CH3:16]

Participants

Conditions

Temperature: 80 °C

Procedure

To a chloroform solution (5 ml) of 1-(4-isopropylphenyl)-3-methyl-5-pyrazolone (108 mg, 0.5 mmol), methyl trifluoropyruvate (78 mg, 0.5 mmol) was added at room temperature and the mixture was stirred at 80° C. for 2 hours. After removing the solvent under reduced pressure, the title compound was obtained as a pale yellow solid (186 mg).

Workup

customAfter removing the solvent under reduced pressure

Sources & evidence

ORD record: ord-456a6fb3e6064ff195a0364a660882c2
Source dataset: uspto-grants-2012_01
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08106086B2

Reaction notes

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