1,4-Dioxane hydrochloride → HCID 90656935, compound

HRID 424964Notes

Reaction equation

HRID 424964 reaction equation
[CH:1]1([C:16]([O:18][CH2:19][CH3:20])=[O:17])[CH:5]2[CH2:6][CH2:7][CH2:8][CH:4]2[CH2:3][N:2]1C(OC(C)(C)C)=O.[ClH:21].O1CCOCC1>>[ClH:21].[CH:1]1([C:16]([O:18][CH2:19][CH3:20])=[O:17])[CH:5]2[CH2:6][CH2:7][CH2:8][CH:4]2[CH2:3][NH:2]1

Participants

3

Reactant 2

HCID 204431481,4-Dioxane hydrochlorideHCID 66705287HCID 66705287, compound2×

Product 1

HCID 90656935HCID 90656935, compound

Procedure

The product of Step 4, 2-tert-butyl 1-ethyl hexahydrocyclopenta[c]pyrrole-1,2(1H)-dicarboxylate, was dissolved in anhydrous 4N hydrochloric acid/dioxane for 1 hour at room temperature, and the solvent removed under reduced pressure, to provide racemic (1S,3aR,6aS)-ethyl octahydrocyclopenta[c]pyrrole-1-carboxylate hydrochloride as a white solid.

Workup

  1. customthe solvent removed under reduced pressure

Sources & evidence

ORD record
ord-58a528a849f6411f988c4e9965372d08
Source dataset
uspto-grants-2012_01
Patent number
US08106059B2

Reaction notes

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