Methyl 2-(3-cyclohexyl-1,1,1-trifluoro-3-nitropropan-2-ylamino)-3,3-dimethylbutanoate → Methyl 2-(3-amino-3-cyclohexyl-1,1,1-trifluoropropan-2-ylamino)-3,3-dimethylbutanoate

Participants

Reaction Steps

Methyl 2-(3-cyclohexyl-1,1,1-trifluoro-3-nitropropan-2-ylamino)-3,3-dimethylbutanoate (isomer 5B1, 0.3 gm) in ethanol (30 mL) was hydrogenated over Raney Ni catalyst at 50 psi for 20 hours. The catalyst was filtered off and the filtrate was evaporated to dryness under reduced pressure, to provide crude methyl 2-(3-amino-3-cyclohexyl-1,1,1-trifluoropropan-2-ylamino)-3,3-dimethylbutanoate (6) which was used in the next reaction with no further purification.

Provenance & Evidence