反应详情

To a stirred solution of (R,R)-1-benzyl-3-chloro-2-hydroxypropylcarbamic acid tert-butyl ester (4.45 g, 15 mmol) in ethanol (125 mL) at 0° C. is added KOH (0.5M in ethanol, 36 ml, 18 mmol). After stirring for 20 min, the mixture is concentrated under reduced pressure and the residue is dissolved in ethyl acetate, washed with saturated ammonium chloride (aq), water and then brine, dried over Na2SO4 and concentrated under reduced pressure. The resulting white solid is purified using General Purification Procedure E to afford the title compound as a white solid (2.7 g, 10.4 mmol).

1. concentrationthe mixture is concentrated under reduced pressure
2. dissolutionthe residue is dissolved in ethyl acetate
3. washwashed with saturated ammonium chloride (aq), water
4. dry with materialbrine, dried over Na2SO4
5. concentrationconcentrated under reduced pressure
6. customThe resulting white solid is purified
7. customGeneral Purification Procedure E