4-Nitrophenol → HCID 66703782, compound

Participants

Reaction Steps

To a solution of (R)-2-tert-butoxycarbonylamino-3-(2,5-difluorophenyl)-propionic acid (8.0 g, 27 mmol) in anhydrous dichloromethane (200 mL) at 0° C. is added N-ethyl-N′,N′-dimethylaminoethyl carbodiimide (5.09 g, 27 mmol), followed by 4-nitrophenol (4.4 g, 32 mmol). After stirring for 30 min, the solution is washed sequentially with saturated NaHCO3 (aq), water, 1.0 M citric acid (aq), water and brine, then dried over Na2SO4 and concentrated under reduced pressure to afford the title compound as a slightly red solid (8.11 g, 19 mmol), contaminated with residual 4-nitrophenol, which may be used without purification.

Provenance & Evidence