HuagongsheHuagongshe Chemistry Print Report · For research reference only
1H-1,2,4-Triazole → [(1R,2S)-1-Benzyl-2-hydroxy-3-[1,2,4]triazol-1-yl-propyl]-carbamic acid tert-butyl ester
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1H-1,2,4-Triazole | HCID 9257 | — |
| Reactant | erythro-N-Boc-D-phenylalanine epoxide | HCID 11357515 | — |
| Product | [(1R,2S)-1-Benzyl-2-hydroxy-3-[1,2,4]triazol-1-yl-propyl]-carbamic acid tert-butyl ester | HCID 66703587 | — |
Reaction Steps
Using general procedure 4 with [(1R)-1-{(2R)-oxiran-2-yl}-2-phenyl-ethyl]carbamic acid tert-butylester (0.125 g, 0.47 mmol) and 1,2,4-triazole (0.036 g, 0.52 mmol) gives the title compound (recrystallized from ethyl acetate).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08106090B2 |
| Source dataset | uspto-grants-2012_01 |
| ORD ID | ord-0dcba0a512df481fa14f190895fc4b44 |
| Source note | uspto-grants-2012_01 |