HuagongsheHuagongshe Chemistry Print Report · For research reference only
L-Prolinamide → [(1R,2S)-1-Benzyl-3-([2S]-2-carbamoyl-pyrrolidin-1-yl)-2-hydroxy-propyl]-carbamic acid tert-butyl ester
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | L-Prolinamide | HCID 111306 | — |
| Reactant | erythro-N-Boc-D-phenylalanine epoxide | HCID 11357515 | — |
| Product | [(1R,2S)-1-Benzyl-3-([2S]-2-carbamoyl-pyrrolidin-1-yl)-2-hydroxy-propyl]-carbamic acid tert-butyl ester | HCID 66703646 | — |
Reaction Steps
Using general procedure 1 and purification method D with [(1R)-1-{(2R)-oxiran-2-yl}-2-phenyl-ethyl]carbamic acid tert-butylester (0.10 g, 0.38 mmol) and (S)-proline amide (0.114 g, 0.57 mmol) gives the title compound.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08106090B2 |
| Source dataset | uspto-grants-2012_01 |
| ORD ID | ord-c1aac20363f64239b064bf073c992b70 |
| Source note | uspto-grants-2012_01 |