(S)-2-(4-Fluorophenyl)pyrrolidine → HCID 86622775, compound

HRID 424996Notes

Reaction equation

HRID 424996 reaction equation
[C:1]([O:5][C:6](=[O:19])[NH:7][C@@H:8]([C@@H:16]1[CH2:18][O:17]1)[CH2:9][C:10]1[CH:15]=[CH:14][CH:13]=[CH:12][CH:11]=1)([CH3:4])([CH3:3])[CH3:2].[F:20][C:21]1[CH:26]=[CH:25][C:24]([C@@H:27]2[CH2:31][CH2:30][CH2:29][NH:28]2)=[CH:23][CH:22]=1>>[C:1]([O:5][C:6](=[O:19])[NH:7][C@H:8]([CH2:9][C:10]1[CH:15]=[CH:14][CH:13]=[CH:12][CH:11]=1)[C@@H:16]([OH:17])[CH2:18][N:28]1[CH2:29][CH2:30][CH2:31][C@H:27]1[C:24]1[CH:25]=[CH:26][C:21]([F:20])=[CH:22][CH:23]=1)([CH3:4])([CH3:3])[CH3:2]

Participants

3

Reactant 2

HCID 7022776(S)-2-(4-Fluorophenyl)pyrrolidineHCID 11357515erythro-N-Boc-D-phenylalanine epoxide

Product 1

HCID 86622775HCID 86622775, compound

Procedure

Using general procedure 1 and purification method D with [(1R)-1-{(2R)-oxiran-2-yl}-2-phenyl-ethyl]carbamic acid tert-butylester (0.10 g, 0.38 mmol) and (2S)-2-(4-fluorophenyl)-pyrrolidine (0.10 g, 0.60 mmol) gives the title compound.

Sources & evidence

ORD record
ord-32268d23e92b44fcbe855d04b3a12307
Source dataset
uspto-grants-2012_01
Patent number
US08106090B2

Reaction notes

Loading…