HuagongsheHuagongshe Chemistry Print Report · For research reference only
(S)-(+)-2-(Methoxymethyl)pyrrolidine → [(1R,2S)-1-Benzyl-2-hydroxy-3-([2S]-2-methoxymethyl-pyrrolidin-1-yl)-propyl]-carbamic acid tert-butyl ester
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | (S)-(+)-2-(Methoxymethyl)pyrrolidine | HCID 671217 | — |
| Reactant | erythro-N-Boc-D-phenylalanine epoxide | HCID 11357515 | — |
| Product | [(1R,2S)-1-Benzyl-2-hydroxy-3-([2S]-2-methoxymethyl-pyrrolidin-1-yl)-propyl]-carbamic acid tert-butyl ester | HCID 66703734 | — |
Reaction Steps
Using general procedure 1 and purification method D with [(1R)-1-{(2R)-oxiran-2-yl}-2-phenyl-ethyl]carbamic acid tert-butylester (0.10 g, 0.38 mmol) and (2S)-2-methoxymethyl-pyrrolidine (0.087 g, 0.76 mmol) gives the title compound.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08106090B2 |
| Source dataset | uspto-grants-2012_01 |
| ORD ID | ord-087be42f93784f70ab9a7046cde33b95 |
| Source note | uspto-grants-2012_01 |