HuagongsheHuagongshe Chemistry Print Report · For research reference only
Methylamine → [(1R,2S)-1-Benzyl-2-hydroxy-3-methylamino-propyl]-carbamic acid tert-butyl ester
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Methylamine | HCID 6329 | — |
| Reactant | erythro-N-Boc-D-phenylalanine epoxide | HCID 11357515 | — |
| Product | [(1R,2S)-1-Benzyl-2-hydroxy-3-methylamino-propyl]-carbamic acid tert-butyl ester | HCID 66703655 | — |
Reaction Steps
Using general procedure 1 with [(1R)-1-{(2R)-oxiran-2-yl}-2-phenyl-ethyl]carbamic acid tert-butylester (0.50 g, 1.9 mmol) and methylamine (10 mL, 8 M solution in ethanol, mmol; used as solvent) gives the title compound.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08106090B2 |
| Source dataset | uspto-grants-2012_01 |
| ORD ID | ord-9d07d4661392404e8e5f959cfa4f623e |
| Source note | uspto-grants-2012_01 |