HCID 10888348, compound → HCID 66703759, compound

HRID 425000Notes

Reaction equation

HRID 425000 reaction equation
[C:1]([O:5][C:6](=[O:19])[NH:7][C@@H:8]([C@@H:16]1[CH2:18][O:17]1)[CH2:9][C:10]1[CH:15]=[CH:14][CH:13]=[CH:12][CH:11]=1)([CH3:4])([CH3:3])[CH3:2].[C:20]([NH:24][C:25](=[O:31])[C@@H:26]1[CH2:30][CH2:29][CH2:28][NH:27]1)([CH3:23])([CH3:22])[CH3:21]>>[C:1]([O:5][C:6](=[O:19])[NH:7][C@H:8]([CH2:9][C:10]1[CH:15]=[CH:14][CH:13]=[CH:12][CH:11]=1)[C@@H:16]([OH:17])[CH2:18][N:27]1[CH2:28][CH2:29][CH2:30][C@H:26]1[C:25](=[O:31])[NH:24][C:20]([CH3:22])([CH3:21])[CH3:23])([CH3:4])([CH3:3])[CH3:2]

Participants

3

Reactant 2

HCID 10888348HCID 10888348, compoundHCID 11357515erythro-N-Boc-D-phenylalanine epoxide

Product 1

HCID 66703759HCID 66703759, compound

Procedure

Using general procedure 1 and purification method D with [(1R)-1-{(2R)-oxiran-2-yl}-2-phenyl-ethyl]carbamic acid tert-butylester (0.21 g, 0.80 mmol) and (S)-proline tert-butyl amide (0.15 g, 0.88 mmol) gives the title compound.

Sources & evidence

ORD record
ord-13a112df9feb4c609d0eb6fd2735fb0f
Source dataset
uspto-grants-2012_01
Patent number
US08106090B2

Reaction notes

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