Morpholine → HCID 66703623, compound

HRID 425009Notes

Reaction equation

HRID 425009 reaction equation
[C:1]([O:5][C:6](=[O:19])[NH:7][C@@H:8]([C@@H:16]1[CH2:18][O:17]1)[CH2:9][C:10]1[CH:15]=[CH:14][CH:13]=[CH:12][CH:11]=1)([CH3:4])([CH3:3])[CH3:2].[NH:20]1[CH2:25][CH2:24][O:23][CH2:22][CH2:21]1>>[C:1]([O:5][C:6](=[O:19])[NH:7][C@H:8]([CH2:9][C:10]1[CH:15]=[CH:14][CH:13]=[CH:12][CH:11]=1)[C@@H:16]([OH:17])[CH2:18][N:20]1[CH2:25][CH2:24][O:23][CH2:22][CH2:21]1)([CH3:4])([CH3:3])[CH3:2]

Participants

3

Reactant 2

HCID 8083MorpholineHCID 11357515erythro-N-Boc-D-phenylalanine epoxide

Product 1

HCID 66703623HCID 66703623, compound

Procedure

Using general procedure 1 with [(1R)-1-{(2R)-oxiran-2-yl}-2-phenyl-ethyl]carbamic acid tert-butylester (0.133 g, 0.50 mmol) and morpholine (0.220 mL, 2.50 mmol) gives the title compound.

Sources & evidence

ORD record
ord-ecb4adfe44ba446db159ef668b6a89d7
Source dataset
uspto-grants-2012_01
Patent number
US08106090B2

Reaction notes

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