HCID 10888348, compound → HCID 66703756, compound

HRID 425010Notes

Reaction equation

HRID 425010 reaction equation
[C:1]([O:5][C:6](=[O:21])[NH:7][C@@H:8]([C@@H:18]1[CH2:20][O:19]1)[CH2:9][C:10]1[CH:15]=[C:14]([F:16])[CH:13]=[CH:12][C:11]=1[F:17])([CH3:4])([CH3:3])[CH3:2].[C:22]([NH:26][C:27](=[O:33])[C@@H:28]1[CH2:32][CH2:31][CH2:30][NH:29]1)([CH3:25])([CH3:24])[CH3:23]>>[C:1]([O:5][C:6](=[O:21])[NH:7][C@H:8]([CH2:9][C:10]1[CH:15]=[C:14]([F:16])[CH:13]=[CH:12][C:11]=1[F:17])[C@@H:18]([OH:19])[CH2:20][N:29]1[CH2:30][CH2:31][CH2:32][C@H:28]1[C:27](=[O:33])[NH:26][C:22]([CH3:24])([CH3:23])[CH3:25])([CH3:4])([CH3:3])[CH3:2]

Participants

3

Reactant 2

HCID 10888348HCID 10888348, compoundHCID 59786775HCID 59786775, compound

Product 1

HCID 66703756HCID 66703756, compound

Procedure

Using general procedure 1 and purification method D with [(1R)-1-{(2R)-oxiran-2-yl}-2-(2,5-difluoro-phenyl)-ethyl]carbamic acid tert-butylester (0.213 g, 0.71 mmol) and (S)-proline tert-butyl amide (0.133 g, 0.78 mmol) gives the title compound.

Sources & evidence

ORD record
ord-ea3ae53ba8b74c2b9eecd71768786104
Source dataset
uspto-grants-2012_01
Patent number
US08106090B2

Reaction notes

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