Acetyl chloride → HCID 66703704, compound

HRID 425013Notes

Reaction equation

[C:1]([O:5][C:6](=[O:23])[NH:7][C@H:8]([CH2:14][C:15]1[CH:20]=[C:19]([F:21])[CH:18]=[CH:17][C:16]=1[F:22])[C@@H:9]([OH:13])[CH2:10][NH:11][CH3:12])([CH3:4])([CH3:3])[CH3:2].[C:24](Cl)(=[O:26])[CH3:25]>>[C:1]([O:5][C:6](=[O:23])[NH:7][C@H:8]([CH2:14][C:15]1[CH:20]=[C:19]([F:21])[CH:18]=[CH:17][C:16]=1[F:22])[C@@H:9]([OH:13])[CH2:10][N:11]([C:24](=[O:26])[CH3:25])[CH3:12])([CH3:4])([CH3:2])[CH3:3]

Participants

Reactant 2

HCID 6367Acetyl chloride

HCID 66703725HCID 66703725, compound

Product 1

HCID 66703704HCID 66703704, compound

Procedure

Using general procedure 5 with [(1R,2S)-1-(2,5-difluoro-benzyl)-2-hydroxy-3-methylamino-propyl]-carbamic acid tert-butyl ester (0.107 g, 0.32 mmol) and acetyl chloride (0.020 mL, 0.32 mmol) gives the title compound.

Sources & evidence

ORD record: ord-c5ea63d08a434887aa943bea3fe8175e
Source dataset: uspto-grants-2012_01
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08106090B2

Reaction notes

Loading…