HRID425027

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID2756886

1-bromo-2-chloro-4-iodobenzene

C6H3BrClI

结构：CC(C)(C)OC(=O)N[C@@H](C/C=C/c1ccc(B2OC(C)(C)C(C)(C)O2)cc1)C(=O)OC1CCCC1

HCID59243623

未命名化合物

PRODUCTS

生成物

结构：CC(C)(C)OC(=O)N[C@@H](C/C=C/c1ccc(B2OC(C)(C)C(C)(C)O2)c(Cl)c1)C(=O)OC1CCCC1

HCID59243614

未命名化合物

PROCEDURE

实验过程

Synthesised by analogous methods to Intermediate 5a, using 4-bromo-3-chloro-iodobenzene at Stage 2 of Scheme 4. m/z 520 [M+H]+.

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-d9d211573f194dd7844e1b7414845a50
来源数据集: uspto-grants-2012_01
DOI: 10.6084/m9.figshare.5104873.v1
专利: US08106091B2
来源说明: uspto-grants-2012_01

反应 SMILES

[C:1]([O:5][C:6]([NH:8][C@@H:9]([CH2:18]/[CH:19]=[CH:20]/[C:21]1[CH:26]=[CH:25][C:24]([B:27]2[O:31][C:30]([CH3:33])([CH3:32])[C:29]([CH3:35])([CH3:34])[O:28]2)=[CH:23][CH:22]=1)[C:10]([O:12][CH:13]1[CH2:17][CH2:16][CH2:15][CH2:14]1)=[O:11])=[O:7])([CH3:4])([CH3:3])[CH3:2].BrC1C=CC(I)=CC=1[Cl:44]>>[C:1]([O:5][C:6]([NH:8][C@@H:9]([CH2:18]/[CH:19]=[CH:20]/[C:21]1[CH:26]=[CH:25][C:24]([B:27]2[O:31][C:30]([CH3:33])([CH3:32])[C:29]([CH3:35])([CH3:34])[O:28]2)=[C:23]([Cl:44])[CH:22]=1)[C:10]([O:12][CH:13]1[CH2:17][CH2:16][CH2:15][CH2:14]1)=[O:11])=[O:7])([CH3:4])([CH3:2])[CH3:3]