2',4'-Dihydroxyacetophenone → 2'-Hydroxy-4'-(ethoxycarbonyldimethylmethoxy)acetophenone

HRID 425103Notes

Reaction equation

HRID 425103 reaction equation
[OH:1][C:2]1[CH:7]=[C:6]([OH:8])[CH:5]=[CH:4][C:3]=1[C:9](=[O:11])[CH3:10].Br[C:13]([CH3:20])([CH3:19])[C:14]([O:16][CH2:17][CH3:18])=[O:15]>>[OH:1][C:2]1[CH:7]=[C:6]([O:8][C:13]([C:14]([O:16][CH2:17][CH3:18])=[O:15])([CH3:20])[CH3:19])[CH:5]=[CH:4][C:3]=1[C:9](=[O:11])[CH3:10]

Participants

3

Reactant 2

HCID 69902',4'-DihydroxyacetophenoneHCID 11745Propanoic acid, 2-bromo-2-methyl-, ethyl ester

Product 1

HCID 577628812'-Hydroxy-4'-(ethoxycarbonyldimethylmethoxy)acetophenone

Procedure

This compound was synthesized from 2′,4′-dihydroxyacetophenone and ethyl bromoisobutyrate (1 eq) according to general method 4 described earlier. It was purified by chromatography on silica gel (elution:cyclohexane/ethyl acetate 9:1).

Workup

  1. customIt was purified by chromatography on silica gel (elution:cyclohexane/ethyl acetate 9:1)

Sources & evidence

ORD record
ord-f7bac267ad8f42648e85255afd51d4a7
Source dataset
uspto-grants-2012_01
Patent number
US08106097B2

Reaction notes

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