HRID425127

反应详情

EQUATION

反应方程式

REACTANTS

反应物

结构：COC(=O)[C@@H]1C[C@H](N=[N+]=[N-])CN1C(=O)OC(C)(C)C

HCID11219435

未命名化合物

PRODUCTS

生成物

结构：COC(=O)[C@@H]1C[C@H](N)CN1C(=O)OC(C)(C)C

HCID5200425

1-tert-Butyl 2-methyl (2S,4S)-4-aminopyrrolidine-1,2-dicarboxylate

C11H20N2O4

收率 96.8%

AUXILIARIES

试剂、催化剂与溶剂

催化剂HCID23938

Palladium

溶剂HCID887

Methanol

CH4O

PROCEDURE

实验过程

(2S,4S)-4-azidopyrrolidine-1,2-dicarboxylic acid 1-t-butyl ester 2-methyl ester (8.5 g, 31 mmol) and Pd/C (10% w/w, 2.0 g) were stirred in MeOH (150 mL) at room temperature under an atmosphere of hydrogen for 48 hours. The mixture was filtered and the filtrate evaporated to afford the title compound (7.34 g, 30 mmol), which was used without further purification. MS m/z: [M+H]+ calcd for C11H20N2O4, 244.3. found 245.3.

WORKUP

后处理

filtrationThe mixture was filtered
customthe filtrate evaporated