HCID 11271378, compound → HCID 66702456, compound

HRID 425242Notes

Reaction equation

HRID 425242 reaction equation
[Br:1][C:2]1[CH:7]=[C:6]([CH3:8])[C:5]([C:9]2[CH:10]=[C:11]([C:27]([NH2:29])=[O:28])[N:12]3[C:17]([NH:18][CH:19]([CH2:23][CH2:24][CH3:25])[CH2:20][CH2:21][CH3:22])=[CH:16][C:15]([CH3:26])=[N:14][C:13]=23)=[C:4]([CH3:30])[CH:3]=1.[ClH:31].C(OCC)(=O)C>C(O)C>[ClH:31].[Br:1][C:2]1[CH:7]=[C:6]([CH3:8])[C:5]([C:9]2[CH:10]=[C:11]([C:27]([NH2:29])=[O:28])[N:12]3[C:17]([NH:18][CH:19]([CH2:23][CH2:24][CH3:25])[CH2:20][CH2:21][CH3:22])=[CH:16][C:15]([CH3:26])=[N:14][C:13]=23)=[C:4]([CH3:30])[CH:3]=1

Participants

4

Reactant 2

HCID 11271378HCID 11271378, compoundHCID 21866389Hydrogen chloride-ethyl acetate

Product 1

HCID 66702456HCID 66702456, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

To a suspension of 8-(4-bromo-2,6-dimethyl-phenyl)-2-methyl-4-(1-propyl-butylamino)-pyrrolo[1,2-a]pyrimidine-6-carboxylic acid amide (5.8 g) in ethanol (30 mL) was added 4 M HCl/ethyl acetate (3.7 mL) in an ice-cooling bath. The resulting solution was concentrated under reduced pressure. The residue was crystallized from ethyl acetate to give the title compound.

Workup

  1. temperaturecooling bath
  2. concentrationThe resulting solution was concentrated under reduced pressure
  3. customThe residue was crystallized from ethyl acetate

Sources & evidence

ORD record
ord-77911e6abf584bbab5668ec284e64f4c
Source dataset
uspto-grants-2012_01
Patent number
US08106194B2

Reaction notes

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