Acetic Anhydride → HCID 66704013, compound

HRID 425262Notes

Reaction equation

HRID 425262 reaction equation
[Cl:1][C:2]1[CH:3]=[C:4]2[C:9](=[CH:10][CH:11]=1)[N:8]=[C:7]([NH:12][CH2:13][CH3:14])[CH:6]=[C:5]2[C:15]1[CH:20]=[CH:19][C:18]([N+:21]([O-:23])=[O:22])=[CH:17][CH:16]=1.[C:24](OC(=O)C)(=[O:26])[CH3:25]>>[Cl:1][C:2]1[CH:3]=[C:4]2[C:9](=[CH:10][CH:11]=1)[N:8]=[C:7]([N:12]([C:24](=[O:26])[CH3:25])[CH2:13][CH3:14])[CH:6]=[C:5]2[C:15]1[CH:20]=[CH:19][C:18]([N+:21]([O-:23])=[O:22])=[CH:17][CH:16]=1

Participants

3

Reactant 2

HCID 7918Acetic AnhydrideHCID 66704006HCID 66704006, compound2×

Product 1

HCID 66704013HCID 66704013, compound

Procedure

600 mg of 6-chloro-2-ethylamino 4-(4-nitrophenyl)quinoline (compound 2a) were added to 0.19 g of acetic anhydride. The mixture was boiled at 70° C. for 4 hours and cooled, and the acetic anhydride was removed by distillation. The residue was mixed with water, extracted with ethyl acetate and washed with water, and the product was obtained as a yellow oil.

Workup

  1. customfor 4 hours
  2. temperaturecooled
  3. customthe acetic anhydride was removed by distillation
  4. additionThe residue was mixed with water
  5. extractionextracted with ethyl acetate
  6. washwashed with water
  7. customthe product was obtained as a yellow oil

Sources & evidence

ORD record
ord-f6cbee7c1f734408bc48ac35add165fa
Source dataset
uspto-grants-2012_01
Patent number
US08106204B2

Reaction notes

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