反应详情

Powered sodium cyanide (12.0 g, 0.24 mol) was dissolved in a 20 mL of water, and was added a solution of 1-bromo-4-(bromomethyl)-2-fluorobenzene (60 g, 0.22 mol) in 30 mL of ethanol. After heating at reflux for 4 h, the reaction mixture was cooled to room temperature and filtered. The filtrate was concentrated, and the residue was diluted with CH2Cl2, filtered, and concentrated to afford (4-bromo-3-fluorophenyl)acetonitrile, which was used without further purification.

1. temperatureAfter heating
2. temperatureat reflux for 4 h
3. filtrationfiltered
4. concentrationThe filtrate was concentrated
5. additionthe residue was diluted with CH2Cl2
6. filtrationfiltered
7. concentrationconcentrated