HCID 178442236, compound → HCID 178442237, compound

HRID 425373Notes

Reaction equation

HRID 425373 reaction equation
[F:1][C:2]1[CH:3]=[CH:4][C:5]([C:8]2[CH:13]=[CH:12][C:11]([CH2:14][C:15]([C:18]3[NH:19][CH:20]=[C:21]([CH2:23][C:24]([CH3:31])([C:27]([F:30])([F:29])[F:28])[CH:25]=[CH2:26])[N:22]=3)([OH:17])[CH3:16])=[CH:10][CH:9]=2)=[N:6][CH:7]=1>CO.[Pd]>[F:1][C:2]1[CH:3]=[CH:4][C:5]([C:8]2[CH:9]=[CH:10][C:11]([CH2:14][C:15]([C:18]3[NH:19][CH:20]=[C:21]([CH2:23][C:24]([CH3:31])([C:27]([F:30])([F:29])[F:28])[CH2:25][CH3:26])[N:22]=3)([OH:17])[CH3:16])=[CH:12][CH:13]=2)=[N:6][CH:7]=1

Participants

4

Reactant 1

HCID 178442236HCID 178442236, compound

Product 1

HCID 178442237HCID 178442237, compound

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 887MethanolSolvent

Procedure

Pd (10 wt % on activated carbon) (catalytic) was added to a degassed, ambient temperature solution of 1-[4-(5-fluoropyridin-2-yl)phenyl]-2-{4-[2-methyl-2-(trifluoromethyl)but-3-en-1-yl]-1H-imidazol-2-yl}propan-2-ol (Example 34) (8 mg, 0.02 mmol) in methanol (1 mL). After stirring at ambient temperature under an atmosphere of hydrogen for 1 h, the reaction mixture was filtered through cotton and concentrated in vacuo to afford the title compound. (M+H) found: 436.

Workup

  1. filtrationthe reaction mixture was filtered through cotton
  2. concentrationconcentrated in vacuo

Sources & evidence

ORD record
ord-7832290e59c6494b9888f9855b9b7f4e
Source dataset
uspto-grants-2012_01
Patent number
US08106070B2

Reaction notes

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