HCID 58872472, compound → HCID 58872483, compound

HRID 425563Notes

Reaction equation

HRID 425563 reaction equation
BrC1C=CC=C2C=1C(C1C(O)=CC3OCOC=3C=1)[C:5](=[O:16])N2CCCCC.[Cl:27][C:28]1[CH:33]=[CH:32][C:31]([CH:34]2[C:42]3[C:37](=[CH:38][CH:39]=[CH:40][CH:41]=3)[N:36]([CH2:43][C:44]([O:46][CH3:47])=[O:45])[C:35]2=[O:48])=[C:30]([OH:49])[CH:29]=1>>[Cl:27][C:28]1[CH:33]=[CH:32][C:31]([C:34]2([CH2:5][OH:16])[C:42]3[C:37](=[CH:38][CH:39]=[CH:40][CH:41]=3)[N:36]([CH2:43][C:44]([O:46][CH3:47])=[O:45])[C:35]2=[O:48])=[C:30]([OH:49])[CH:29]=1

Participants

3

Reactant 2

HCID 58872472HCID 58872472, compoundHCID 588725004-bromo-3-(6-hydroxy-1,3-benzodioxol-5-yl)-1-pentyl-1,3-dihydro-2H-indol-2-one

Product 1

HCID 58872483HCID 58872483, compound

Procedure

Following the procedure as described in PREPARATION 1E, and making non-critical variations to replace 4-bromo-3-(6-hydroxy-1,3-benzodioxol-5-yl)-1-pentyl-1,3-dihydro-2H-indol-2-one with methyl [3-(4-chloro-2-hydroxyphenyl)-2-oxo-2,3-dihydro-1H-indol-1-yl]acetate, the title compound was obtained: MS (ES+) m/z 362.5 (M+1) 364.5 (M+1).

Sources & evidence

ORD record
ord-a962df2e41b54728b17c14c3c344b000
Source dataset
uspto-grants-2012_01
Patent number
US08106087B2

Reaction notes

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