HuagongsheHuagongshe Chemistry Print Report · For research reference only
1-Bromopentane → 7-fluoro-{[5-(trifluoromethyl)-2-furyl]methyl}-1H-indole-2,3-dione
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1-Bromopentane | HCID 8057 | — |
| Reactant | 7-Fluoroisatin | HCID 586418 | — |
| Reactant | 4-Bromoindole | HCID 676494 | — |
| Reactant | 2-(Bromomethyl)-5-(trifluoromethyl)furan | HCID 2794605 | — |
| Product | 7-fluoro-{[5-(trifluoromethyl)-2-furyl]methyl}-1H-indole-2,3-dione | HCID 66642570 | — |
Reaction Steps
Following the procedure as described in PREPARATION 1A, and making tnon-critical variations to replace 4-bromoindole with 7-fluoroisatin, and 1-bromopentane with 2-(bromomethyl)-5-(trifluoromethyl)furan, the title compound was obtained (34%): MS (ES+) m/z 336.2 (M+23).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08106087B2 |
| Source dataset | uspto-grants-2012_01 |
| ORD ID | ord-eeccaab0de1f4b48bffcc4d0c1e23b03 |
| Source note | uspto-grants-2012_01 |