HCID 12004407, compound → HCID 58872447, compound

HRID 425583Notes

Reaction equation

HRID 425583 reaction equation
C1(CCN2C3C(=CC=CC=3)C(O)(C3C(O)=CC4OCOC=4C=3)C2=O)CC1.O[C:28]1([C:43]2[C:44]([OH:52])=[CH:45][C:46]3[O:50][CH2:49][CH2:48][C:47]=3[CH:51]=2)[C:36]2[C:31](=[CH:32][CH:33]=[CH:34][CH:35]=2)[N:30]([CH2:37][CH2:38][CH2:39][CH2:40][CH3:41])[C:29]1=[O:42]>>[OH:52][C:44]1[C:43]([CH:28]2[C:36]3[C:31](=[CH:32][CH:33]=[CH:34][CH:35]=3)[N:30]([CH2:37][CH2:38][CH2:39][CH2:40][CH3:41])[C:29]2=[O:42])=[CH:51][C:47]2[CH2:48][CH2:49][O:50][C:46]=2[CH:45]=1

Participants

3

Reactant 2

HCID 12004407HCID 12004407, compoundHCID 588725381-(2-cyclopropylethyl)-3-hydroxy-3-(6-hydroxy-1,3-benzodioxol-5-yl)-1,3-dihydro-2H-indol-2-one

Product 1

HCID 58872447HCID 58872447, compound

Procedure

Following the procedure as described in PREPARATION 2C, and making non-critical variations to replace 1-(2-cyclopropylethyl)-3-hydroxy-3-(6-hydroxy-1,3-benzodioxol-5-yl)-1,3-dihydro-2H-indol-2-one with 3-hydroxy-3-(6-hydroxy-2,3-dihydro-1-benzofuran-5-yl)-1-pentyl-1,3-dihydro-2H-indol-2-one, the title compound was obtained (76%): MS (ES+) m/z 338.3 (M+1).

Sources & evidence

ORD record
ord-9c01a83372a94b9e8d4213f981f503c8
Source dataset
uspto-grants-2012_01
Patent number
US08106087B2

Reaction notes

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