1-Phenyl-2-(4-pyridyl)vinyl benzoate → HCID 178434374, compound

HRID 42568Notes

Reaction equation

HRID 42568 reaction equation
[NH2:1][C:2]1[NH:3][N:4]=[C:5]([CH3:7])[CH:6]=1.C(O[C:17]([C:25]1[CH:30]=[CH:29][CH:28]=[CH:27][CH:26]=1)=[CH:18][C:19]1[CH:24]=[CH:23][N:22]=[CH:21][CH:20]=1)(=O)C1C=CC=CC=1>>[C:25]1([C:17]2[C:18]([C:19]3[CH:20]=[CH:21][N:22]=[CH:23][CH:24]=3)=[C:17]([C:25]3[CH:30]=[CH:29][CH:28]=[CH:27][CH:26]=3)[N:1]=[C:2]3[NH:3][N:4]=[C:5]([CH3:7])[C:6]=23)[CH:26]=[CH:27][CH:28]=[CH:29][CH:30]=1

Participants

3

Reactant 2

HCID 684443451-Phenyl-2-(4-pyridyl)vinyl benzoateHCID 178418690HCID 178418690, compound

Product 1

HCID 178434374HCID 178434374, compoundYield 16%

Procedure

Following a similar procedure to that described in example 1 method B, but using 3-amino-5-methyl-2H-pyrazole instead of 3-amino-2H-pyrazole and 1-phenyl-2-(4-pyridyl)vinyl benzoate (obtained in reference example 5) instead of 1-(4-fluorophenyl)-2-(4-pyridyl)vinyl 4-fluorobenzoate, the title compound was obtained in solid white form (yield: 16%).

Sources & evidence

ORD record
ord-a2eeb1a8d8734fb3ac1d080b9edbf152
Source dataset
uspto-grants-2013_09
Patent number
US08536194B2

Reaction notes

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