6-(trifluoromethoxy)spiro[1-benzofuran-3,3'-indol]-2'(1'H)one → 6-(trifluoromethoxy)-1'-{[5-(trifluoromethyl)-2-furyl]methyl}spiro[1-benzofuran-3,3'-indol]-2'(1'H)-one

HRID 425700Notes

Reaction equation

HRID 425700 reaction equation
[F:1][C:2]([F:23])([F:22])[O:3][C:4]1[CH:9]=[CH:8][C:7]2[C:10]3([CH2:20][O:21][C:6]=2[CH:5]=1)[C:18]1[C:13](=[CH:14][CH:15]=[CH:16][CH:17]=1)[NH:12][C:11]3=[O:19].BrC1C=CC=C2C=1[C:27]1([C:38]3=CC4OCOC=4[CH:45]=[C:37]3[O:36][CH2:35]1)C(=O)N2>>[F:23][C:2]([F:1])([F:22])[O:3][C:4]1[CH:9]=[CH:8][C:7]2[C:10]3([CH2:20][O:21][C:6]=2[CH:5]=1)[C:18]1[C:13](=[CH:14][CH:15]=[CH:16][CH:17]=1)[N:12]([CH2:45][C:37]1[O:36][C:35]([C:2]([F:23])([F:22])[F:1])=[CH:27][CH:38]=1)[C:11]3=[O:19]

Participants

3

Reactant 2

HCID 119984696-(trifluoromethoxy)spiro[1-benzofuran-3,3'-indol]-2'(1'H)oneHCID 592633724'-bromospiro[furo[2,3-f][1,3]benzodioxole-7,3'-indol]-2'(1H)-one

Product 1

HCID 592633776-(trifluoromethoxy)-1'-{[5-(trifluoromethyl)-2-furyl]methyl}spiro[1-benzofuran-3,3'-indol]-2'(1'H)-one

Procedure

Following the procedure described in EXAMPLE 10.47, and making non-critical variations using 6-(trifluoromethoxy)spiro[1-benzofuran-3,3′-indol]-2′(1′H)-one to replace 4′-bromospiro[furo[2,3-f][1,3]benzodioxole-7,3′-indol]-2′(1′H)-one, the title compound was obtained (82%) as a white solid: mp 78-80° C.; 1H NMR (300 MHz, CDCl3) δ 7.33 (td, 1H), 7.21-6.98 (m, 3H), 6.86-6.73 (m, 2H), 6.67 (s, 2H), 6.42 (d, 1H), 5.09 (d, 1H), 5.04 (d, 1H), 4.88 (d, 1H), 4.77 (d, 1H); 13C NMR (75 MHz, CDCl3) δ 176.7, 161.7, 151.9, 150.6, 141.5, 131.7, 129.5, 127.5, 124.2, 124.2, 124.0, 114.1, 112.8, 112.8, 109.6, 109.2, 104.3, 80.7, 57.6, 37.1; MS (ES+) m/z 470 (M+1).

Sources & evidence

ORD record
ord-af52e5946a6e4aa892ccf3e3ea25ca17
Source dataset
uspto-grants-2012_01
Patent number
US08106087B2

Reaction notes

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