Lithium hydroxide, monohydrate → HCID 136360367, compound

Participants

Reaction Steps

35 mg (0.08 mmol) of 3-(5-Benzo[1,3]dioxol-5-ylmethylene-4-oxo-thiazolidin-2-ylidenesulfamoyl)-thiophene-2-carboxylic acid methyl ester (Example 5) were dissolved in THF/water. 6 mg of LiOH.H2O were added, and the reaction was followed by TLC. After complete saponification the reaction medium was acidified to pH 3.5, where upon the desired compound precipitated. Washing and drying afforded 25 mg (70%) of 3-(5-Benzo[1,3]dioxol-5-ylmethylene-4-oxo-thiazolidin-2-ylidenesulfamoyl)-thiophene-2-carboxylic acid.

Provenance & Evidence