Benzylamine → HCID 136360393, compound

HRID 425768Notes

Reaction equation

HRID 425768 reaction equation
[O:1]1[C:5]2[CH:6]=[CH:7][C:8]([CH:10]=[C:11]3[S:15][C:14](=S)[NH:13][C:12]3=[O:17])=[CH:9][C:4]=2[O:3][CH2:2]1.C([O-])([O-])=O.[Na+].[Na+].[CH2:24]([NH2:31])[C:25]1[CH:30]=[CH:29][CH:28]=[CH:27][CH:26]=1>CCO.O>[O:1]1[C:5]2[CH:6]=[CH:7][C:8]([CH:10]=[C:11]3[S:15][C:14](=[N:31][CH2:24][C:25]4[CH:30]=[CH:29][CH:28]=[CH:27][CH:26]=4)[NH:13][C:12]3=[O:17])=[CH:9][C:4]=2[O:3][CH2:2]1

Participants

5

Reactant 3

HCID 7504BenzylamineHCID 10340Sodium CarbonateHCID 2785114HCID 2785114, compound

Product 1

HCID 136360393HCID 136360393, compound

Reagents, catalysts & solvents 1

HCID 19096565Water ethanolSolvent

Procedure

5-Benzo[1,3]dioxol-5-ylmethylene-2-thioxo-thiazolidin-4-one (100 mg, 0.37 mmol) were dissolved in EtOH/water, followed by 60 mg of Na2CO3. The reaction was stirred for 30 min and benzylamine (122 μl, 3 eq.) was added. The reaction mixture was refluxed for 2 h. and the solvents were evaporated. The crude was purified by Parallel Flex chromatography.

Workup

  1. temperatureThe reaction mixture was refluxed for 2 h.
  2. customthe solvents were evaporated
  3. customThe crude was purified by Parallel Flex chromatography

Sources & evidence

ORD record
ord-ef0a804a94444f5f94c08ac2db3cb333
Source dataset
uspto-grants-2012_01
Patent number
US08106214B2

Reaction notes

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