Back
HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 425825Generated: October 26, 2026

3-(Trifluoromethoxy)benzoic acid → (1S,2S,5R)-N-[7-Methyl-3-(2-methyl-5-m-tolyl-thiazole-4-carbonyl)-3-aza-bicyclo[3.3.0]oct-2-ylmethyl]-3-trifluoromethoxy-benzamide

https://huagongshe.com/reaction/425825

Reaction equation

Participants

RoleNameHCIDCharge
Reactant3-(Trifluoromethoxy)benzoic acidHCID 66096—
Reactant[(1S,2S,5R)-2-aminomethyl-7-methyl-3-aza-bicyclo[3.3.0]oct-3-yl]-(2-methyl-5-m-tolyl-thiazol-4-yl)-methanoneHCID 59411601—
Product(1S,2S,5R)-N-[7-Methyl-3-(2-methyl-5-m-tolyl-thiazole-4-carbonyl)-3-aza-bicyclo[3.3.0]oct-2-ylmethyl]-3-trifluoromethoxy-benzamideHCID 25154227—

Reaction Steps

prepared by reaction of [(1S,2S,5R)-2-aminomethyl-7-methyl-3-aza-bicyclo[3.3.0]oct-3-yl]-(2-methyl-5-m-tolyl-thiazol-4-yl)-methanone with 3-(trifluoromethoxy)-benzoic acid

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS08106215B2
Source datasetuspto-grants-2012_01
ORD IDord-4fe21a7cc8f04800a3067dea5cd9f436
Source noteuspto-grants-2012_01