HuagongsheHuagongshe Chemistry Print Report · For research reference only
Sodium Hydroxide → HCID 25154300, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Sodium Hydroxide | HCID 14798 | — |
| Reactant | 71641-10-6 | HCID 4348547 | — |
| Reactant | [(1S,2S,5R)-2-aminomethyl-7-methyl-3-aza-bicyclo[3.3.0]oct-3-yl]-(2-methyl-5-m-tolyl-thiazol-4-yl)-methanone | HCID 59411601 | — |
| Solvent | Methanol--water (1/1) | HCID 22242641 | — |
| Product | HCID 25154300 | HCID 25154300 | — |
Reaction Steps
prepared by reaction of [(1S,2S,5R)-2-aminomethyl-7-methyl-3-aza-bicyclo[3.3.0]oct-3-yl]-(2-methyl-5-m-tolyl-thiazol-4-yl)-methanone with 2-methyl-benzofuran-4-carboxylic acid which was synthesised by saponification of the corresponding methyl ester derivative (Ishikawa T. et al. Heterocycles 1994, 39, 1, 371-380) with NaOH in a mixture water/MeOH.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08106215B2 |
| Source dataset | uspto-grants-2012_01 |
| ORD ID | ord-59ad326cacf44f9a8f1ad06f13ff9115 |
| Source note | uspto-grants-2012_01 |