2-(3-methoxyphenyl)benzoic Acid → 6-Methyl-imidazo[2,1-b]thiazole-5-carboxylic acid-(1S,2S,5R)-[7-methyl-3-(3'-methoxy-biphenyl-2-carbonyl)-3-aza-bicyclo[3.3.0]oct-2-ylmethyl]-amide

HRID 425862Notes

Reaction equation

HRID 425862 reaction equation
[CH3:1][CH:2]1[CH2:9][C@H:8]2[C@H:4]([CH2:5][NH:6][C@@H:7]2[CH2:10][NH:11][C:12]([C:14]2[N:21]3[C:17]([S:18][CH:19]=[CH:20]3)=[N:16][C:15]=2[CH3:22])=[O:13])[CH2:3]1.[CH3:23][O:24][C:25]1[CH:26]=[C:27]([C:31]2[C:32]([C:37](O)=[O:38])=[CH:33][CH:34]=[CH:35][CH:36]=2)[CH:28]=[CH:29][CH:30]=1>>[CH3:1][CH:2]1[CH2:9][C@H:8]2[C@H:4]([CH2:5][N:6]([C:37]([C:32]3[C:31]([C:27]4[CH:28]=[CH:29][CH:30]=[C:25]([O:24][CH3:23])[CH:26]=4)=[CH:36][CH:35]=[CH:34][CH:33]=3)=[O:38])[C@@H:7]2[CH2:10][NH:11][C:12]([C:14]2[N:21]3[C:17]([S:18][CH:19]=[CH:20]3)=[N:16][C:15]=2[CH3:22])=[O:13])[CH2:3]1

Participants

3

Reactant 2

HCID 27595492-(3-methoxyphenyl)benzoic AcidHCID 594116326-methyl-imidazo[2,1-b]thiazole-5-carboxylic acid-[(1S,2S,5R)-7-methyl-3-aza-bicyclo[3.3.0]oct-2-ylmethyl]-amide

Product 1

HCID 251546176-Methyl-imidazo[2,1-b]thiazole-5-carboxylic acid-(1S,2S,5R)-[7-methyl-3-(3'-methoxy-biphenyl-2-carbonyl)-3-aza-bicyclo[3.3.0]oct-2-ylmethyl]-amide

Procedure

prepared by reaction of 6-methyl-imidazo[2,1-b]thiazole-5-carboxylic acid-[(1S,2S,5R)-7-methyl-3-aza-bicyclo[3.3.0]oct-2-ylmethyl]-amide with commercially available 3′-methoxy-biphenyl-2-carboxylic acid.

Sources & evidence

ORD record
ord-fec304f69d864db4a0ded5dbadb95fe4
Source dataset
uspto-grants-2012_01
Patent number
US08106215B2

Reaction notes

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