2-Amino-5-phenyl-1,3-thiazole-4-carboxylic acid → 6-Methyl-imidazo[2,1-b]thiazole-5-carboxylic acid-(1S,2S,5R)-[3-(2-amino-5-phenyl-thiazole-4-carbonyl)-3-aza-bicyclo[3.3.0]oct-2-ylmethyl]-amide

HRID 425875Notes

Reaction equation

HRID 425875 reaction equation
C[CH:2]1[CH2:9][C@H:8]2[C@H:4]([CH2:5][NH:6][C@@H:7]2[CH2:10][NH:11][C:12]([C:14]2[N:21]3[C:17]([S:18][CH:19]=[CH:20]3)=[N:16][C:15]=2[CH3:22])=[O:13])[CH2:3]1.[NH2:23][C:24]1[S:25][C:26]([C:32]2[CH:37]=[CH:36][CH:35]=[CH:34][CH:33]=2)=[C:27]([C:29]([OH:31])=O)[N:28]=1>>[NH2:23][C:24]1[S:25][C:26]([C:32]2[CH:37]=[CH:36][CH:35]=[CH:34][CH:33]=2)=[C:27]([C:29]([N:6]2[CH2:5][C@H:4]3[C@H:8]([CH2:9][CH2:2][CH2:3]3)[C@H:7]2[CH2:10][NH:11][C:12]([C:14]2[N:21]3[C:17]([S:18][CH:19]=[CH:20]3)=[N:16][C:15]=2[CH3:22])=[O:13])=[O:31])[N:28]=1

Participants

3

Reactant 2

HCID 183229932-Amino-5-phenyl-1,3-thiazole-4-carboxylic acidHCID 594116326-methyl-imidazo[2,1-b]thiazole-5-carboxylic acid-[(1S,2S,5R)-7-methyl-3-aza-bicyclo[3.3.0]oct-2-ylmethyl]-amide

Product 1

HCID 251541136-Methyl-imidazo[2,1-b]thiazole-5-carboxylic acid-(1S,2S,5R)-[3-(2-amino-5-phenyl-thiazole-4-carbonyl)-3-aza-bicyclo[3.3.0]oct-2-ylmethyl]-amide

Procedure

prepared by reaction of 6-methyl-imidazo[2,1-b]thiazole-5-carboxylic acid-[(1S,2S,5R)-7-methyl-3-aza-bicyclo[3.3.0]oct-2-ylmethyl]-amide with 2-amino-5-phenyl-thiazole-4-carboxylic acid.

Sources & evidence

ORD record
ord-83bba3eabb7a493e926f78d562284d3c
Source dataset
uspto-grants-2012_01
Patent number
US08106215B2

Reaction notes

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