2,3-Dihydro-1-benzofuran-4-carboxylic acid → 2,3-Dihydro-benzofuran-4-carboxylic acid-(1S,2S,5R)-[7,7-difluoro-3-(2-methyl-5-m-tolyl-thiazole-4-carbonyl)-3-aza-bicyclo[3.3.0]oct-2-ylmethyl]-amide

Participants

Role	Name	HCID	Charge
Reactant	2,3-Dihydro-1-benzofuran-4-carboxylic acid	HCID 18787444	—
Reactant	(1S,2S,5R)-(2-aminomethyl-7,7-difluoro-3-aza-bicyclo[3.3.0]-oct-3-yl)-(2-methyl-5-m-tolyl-thiazol-4-yl)-methanone	HCID 59411607	—
Product	2,3-Dihydro-benzofuran-4-carboxylic acid-(1S,2S,5R)-[7,7-difluoro-3-(2-methyl-5-m-tolyl-thiazole-4-carbonyl)-3-aza-bicyclo[3.3.0]oct-2-ylmethyl]-amide	HCID 25154154	—

Reaction Steps

prepared by reaction of (1S,2S,5R)-(2-aminomethyl-7,7-difluoro-3-aza-bicyclo[3.3.0]-oct-3-yl)-(2-methyl-5-m-tolyl-thiazol-4-yl)-methanone with 2,3-dihydro-benzofuran-4-carboxylic acid.

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US08106215B2
Source dataset	uspto-grants-2012_01
ORD ID	ord-added624010c47919da8acc8059c4459
Source note	uspto-grants-2012_01