2,3-Dihydro-1,4-benzodioxin-5-carboxylic acid → 2,3-Dihydro-benzo[1,4]dioxine-5-carboxylic acid-(1S,2S,5R)-[7,7-difluoro-3-(2-methyl-5-m-tolyl-thiazole-4-carbonyl)-3-aza-bicyclo[3.3.0]oct-2-ylmethyl]-amide

Participants

Role	Name	HCID	Charge
Reactant	2,3-Dihydro-1,4-benzodioxin-5-carboxylic acid	HCID 78184	—
Reactant	(1S,2S,5R)-(2-aminomethyl-7,7-difluoro-3-aza-bicyclo[3.3.0]-oct-3-yl)-(2-methyl-5-m-tolyl-thiazol-4-yl)-methanone	HCID 59411607	—
Product	2,3-Dihydro-benzo[1,4]dioxine-5-carboxylic acid-(1S,2S,5R)-[7,7-difluoro-3-(2-methyl-5-m-tolyl-thiazole-4-carbonyl)-3-aza-bicyclo[3.3.0]oct-2-ylmethyl]-amide	HCID 25154155	—

Reaction Steps

prepared by reaction of (1S,2S,5R)-(2-aminomethyl-7,7-difluoro-3-aza-bicyclo[3.3.0]-oct-3-yl)-(2-methyl-5-m-tolyl-thiazol-4-yl)-methanone with 2,3-dihydro-benzo[1,4]dioxine-5-carboxylic acid.

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US08106215B2
Source dataset	uspto-grants-2012_01
ORD ID	ord-6b980923e9524fd2bdb6db07c4d864d0
Source note	uspto-grants-2012_01