Methyl iodide → HCID 86606796, compound

HRID 42591Notes

Reaction equation

HRID 42591 reaction equation
[Cl:1][C:2]1[N:7]=[CH:6][C:5]([C:8]2[C:13]([C:14]3[CH:19]=[CH:18][N:17]=[CH:16][CH:15]=3)=[C:12]([C:20]3[CH:21]=[N:22][C:23]([Cl:26])=[CH:24][CH:25]=3)[N:11]=[C:10]3[NH:27][N:28]=[CH:29][C:9]=23)=[CH:4][CH:3]=1.I[CH3:31]>>[Cl:1][C:2]1[N:7]=[CH:6][C:5]([C:8]2[C:13]([C:14]3[CH:15]=[CH:16][N:17]=[CH:18][CH:19]=3)=[C:12]([C:20]3[CH:21]=[N:22][C:23]([Cl:26])=[CH:24][CH:25]=3)[N:11]=[C:10]3[N:27]([CH3:31])[N:28]=[CH:29][C:9]=23)=[CH:4][CH:3]=1

Participants

3

Reactant 2

HCID 6328Methyl iodideHCID 85995069HCID 85995069, compound

Product 1

HCID 86606796HCID 86606796, compound

Procedure

Following a similar procedure to that described in examples 73 and 74, but using 4,6-bis(6-chloropyridin-3-yl)-5-(4-pyridyl)-1H-pyrazolo[3,4-b]pyridine (obtained in example 40) instead of 4,6-bis(4-fluorophenyl)-5-(4-pyridyl)-1H-pyrazolo[3,4-b]pyridine and iodomethane instead of 2-bromo-1,1-diethoxyethane, the title compounds were obtained.

Sources & evidence

ORD record
ord-d0757aa193574e6fb0b4288f9a874cee
Source dataset
uspto-grants-2013_09
Patent number
US08536194B2

Reaction notes

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