1-(6-Chloropyridin-3-yl)-2-(4-pyridyl)ethanone → HCID 178434375, compound

HRID 42592Notes

Reaction equation

HRID 42592 reaction equation
[Cl:1][C:2]1[N:7]=[CH:6][C:5]([C:8](=O)[CH2:9][C:10]2[CH:15]=[CH:14][N:13]=[CH:12][CH:11]=2)=[CH:4][CH:3]=1.[NH2:17][C:18]1[NH:19][N:20]=[C:21]([CH3:23])[CH:22]=1>>[Cl:1][C:2]1[N:7]=[CH:6][C:5]([C:8]2[C:9]([C:10]3[CH:15]=[CH:14][N:13]=[CH:12][CH:11]=3)=[C:8]([C:5]3[CH:6]=[N:7][C:2]([Cl:1])=[CH:3][CH:4]=3)[N:17]=[C:18]3[NH:19][N:20]=[C:21]([CH3:23])[C:22]=23)=[CH:4][CH:3]=1

Participants

3

Reactant 2

HCID 804610571-(6-Chloropyridin-3-yl)-2-(4-pyridyl)ethanoneHCID 178418690HCID 178418690, compound

Product 1

HCID 178434375HCID 178434375, compoundYield 9%

Procedure

Following a similar procedure to that described in example 1 method A, but using 1-(6-chloropyridin-3-yl)-2-(4-pyridyl)ethanone (obtained in example reference 9) instead of 1-(4-fluorophenyl)-2-(4-pyridyl)ethanone and 3-amino-5-methyl-2H-pyrazole instead of 3-amino-2H-pyrazole, the title compound was obtained (yield: 9%).

Sources & evidence

ORD record
ord-1d8b75f94e1242c59c2ba0646466dece
Source dataset
uspto-grants-2013_09
Patent number
US08536194B2

Reaction notes

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