4-[6-Amino-5-(2,6-dichloro-benzyloxy)-pyridin-3-yl]-benzoic acid → 4-[6-Amino-5-(2,6-dichloro-benzyloxy)-pyridin-3-yl]-N-(2-hydroxy-3-pyrrolidin-1-yl-propyl)-benzamide

HRID 425929Notes

Reaction equation

HRID 425929 reaction equation
[NH2:1][C:2]1[N:7]=[CH:6][C:5]([C:8]2[CH:16]=[CH:15][C:11]([C:12](O)=[O:13])=[CH:10][CH:9]=2)=[CH:4][C:3]=1[O:17][CH2:18][C:19]1[C:24]([Cl:25])=[CH:23][CH:22]=[CH:21][C:20]=1[Cl:26].[NH2:27][CH2:28][CH:29]([OH:36])[CH2:30][N:31]1[CH2:35][CH2:34][CH2:33][CH2:32]1>>[NH2:1][C:2]1[N:7]=[CH:6][C:5]([C:8]2[CH:9]=[CH:10][C:11]([C:12]([NH:27][CH2:28][CH:29]([OH:36])[CH2:30][N:31]3[CH2:35][CH2:34][CH2:33][CH2:32]3)=[O:13])=[CH:15][CH:16]=2)=[CH:4][C:3]=1[O:17][CH2:18][C:19]1[C:20]([Cl:26])=[CH:21][CH:22]=[CH:23][C:24]=1[Cl:25]

Participants

3

Reactant 2

HCID 103181294-[6-Amino-5-(2,6-dichloro-benzyloxy)-pyridin-3-yl]-benzoic acidHCID 121749931-Amino-3-(pyrrolidin-1-yl)propan-2-ol

Product 1

HCID 99839974-[6-Amino-5-(2,6-dichloro-benzyloxy)-pyridin-3-yl]-N-(2-hydroxy-3-pyrrolidin-1-yl-propyl)-benzamide

Procedure

4-[6-Amino-5-(2,6-dichloro-benzyloxy)-pyridin-3-yl]-N-(2-hydroxy-3-pyrrolidin-1-yl-propyl)-benzamide was prepared from 4-[6-amino-5-(2,6-dichloro-benzyloxy)-pyridin-3-yl]-benzoic acid and 1-amino-3-pyrrolidin-1-yl-propan-2-ol following procedure 4.

Sources & evidence

ORD record
ord-a002059a4c804d6c8e26c80f21c908c9
Source dataset
uspto-grants-2012_01
Patent number
US08106197B2

Reaction notes

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