1-Morpholino-3-(4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenoxy)propan-2-ol → 1-(4-{6-Amino-5-[1-(2,6-dichloro-3-fluoro-phenyl)-ethoxy]-pyridin-3-yl}-phenoxy)-3-morpholin-4-yl-propan-2-ol

HRID 425949Notes

Reaction equation

HRID 425949 reaction equation
Br[C:2]1[CH:3]=[C:4]([O:9][CH:10]([C:12]2[C:17]([Cl:18])=[CH:16][CH:15]=[C:14]([F:19])[C:13]=2[Cl:20])[CH3:11])[C:5]([NH2:8])=[N:6][CH:7]=1.[N:21]1([CH2:27][CH:28]([OH:46])[CH2:29][O:30][C:31]2[CH:36]=[CH:35][C:34](B3OC(C)(C)C(C)(C)O3)=[CH:33][CH:32]=2)[CH2:26][CH2:25][O:24][CH2:23][CH2:22]1>>[NH2:8][C:5]1[N:6]=[CH:7][C:2]([C:34]2[CH:35]=[CH:36][C:31]([O:30][CH2:29][CH:28]([OH:46])[CH2:27][N:21]3[CH2:22][CH2:23][O:24][CH2:25][CH2:26]3)=[CH:32][CH:33]=2)=[CH:3][C:4]=1[O:9][CH:10]([C:12]1[C:17]([Cl:18])=[CH:16][CH:15]=[C:14]([F:19])[C:13]=1[Cl:20])[CH3:11]

Participants

3

Reactant 2

HCID 211113791-Morpholino-3-(4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenoxy)propan-2-olHCID 211114785-Bromo-3-(1-(2,6-dichloro-3-fluorophenyl)ethoxy)pyridin-2-amine

Product 1

HCID 211107371-(4-{6-Amino-5-[1-(2,6-dichloro-3-fluoro-phenyl)-ethoxy]-pyridin-3-yl}-phenoxy)-3-morpholin-4-yl-propan-2-ol

Procedure

1-(4-{6-Amino-5-[1-(2,6-dichloro-3-fluoro-phenyl)-ethoxy]-pyridin-3-yl}-phenoxy)-3-morpholin-4-yl-propan-2-ol was prepared following procedure 3 starting from 5-bromo-3-[1-(2,6-dichloro-3-fluoro-phenyl)-ethoxy]-pyridin-2-ylamine and 1-morpholin-4-yl-3-[4-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)-phenoxy]-propan-2-ol.

Sources & evidence

ORD record
ord-aa983ab807544f60b29d04e5e6dcdf97
Source dataset
uspto-grants-2012_01
Patent number
US08106197B2

Reaction notes

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