1-Pyrrolidineethanamine → 4-{6-Amino-5-[1-(2,6-dichloro-phenyl)-ethoxy]-pyridin-3-yl}-N-(2-pyrrolidin-1-yl-ethyl)-benzamide

HRID 425951Notes

Reaction equation

[NH2:1][C:2]1[N:7]=[CH:6][C:5]([C:8]2[CH:16]=[CH:15][C:11]([C:12](O)=[O:13])=[CH:10][CH:9]=2)=[CH:4][C:3]=1[O:17][CH:18]([C:20]1[C:25]([Cl:26])=[CH:24][CH:23]=[CH:22][C:21]=1[Cl:27])[CH3:19].[N:28]1([CH2:33][CH2:34][NH2:35])[CH2:32][CH2:31][CH2:30][CH2:29]1>>[NH2:1][C:2]1[N:7]=[CH:6][C:5]([C:8]2[CH:16]=[CH:15][C:11]([C:12]([NH:35][CH2:34][CH2:33][N:28]3[CH2:32][CH2:31][CH2:30][CH2:29]3)=[O:13])=[CH:10][CH:9]=2)=[CH:4][C:3]=1[O:17][CH:18]([C:20]1[C:21]([Cl:27])=[CH:22][CH:23]=[CH:24][C:25]=1[Cl:26])[CH3:19]

Participants

Reactant 2

HCID 13441-Pyrrolidineethanamine

HCID 21110891HCID 21110891, compound

Product 1

HCID 211108944-{6-Amino-5-[1-(2,6-dichloro-phenyl)-ethoxy]-pyridin-3-yl}-N-(2-pyrrolidin-1-yl-ethyl)-benzamide

Procedure

4-{6-Amino-5-[1-(2,6-dichloro-phenyl)-ethoxy]-pyridin-3-yl}-N-(2-pyrrolidin-1-yl-ethyl)-benzamide was prepared following procedure 4 starting from 4-{6-amino-5-[1-(2,6-dichloro-phenyl)-ethoxy]-pyridin-3-yl}-benzoic acid and 2-pyrrolidin-1-yl-ethylamine.

Sources & evidence

ORD record: ord-8987a991cf134e7d98df8266d0be4816
Source dataset: uspto-grants-2012_01
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08106197B2

Reaction notes

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