HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 425960Generated: October 30, 2026
Cyclopentylamine → HCID 66703625, compound
https://huagongshe.com/reaction/425960
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Cyclopentylamine | HCID 2906 | — |
| Reactant | Potassium Carbonate | HCID 11430 | — |
| Reactant | 4-Bromo-2-fluorobenzonitrile | HCID 736029 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | HCID 66703625 | HCID 66703625 | — |
Reaction Steps
Cyclopentylamine and potassium carbonate were added to a DMF solution of 4-bromo-2-fluorobenzonitrile, followed by stirring at 60° C. By post-treating the reaction liquid, 4-bromo-2-(cyclohexylamino)benzonitrile was obtained. By making reference to the method described in J. Am. Chem. Soc.; 1996; 118; 7215-7216, this was allowed to react with piperidine to obtain 2-(cyclohexylamino)-4-piperidin-1-ylbenzonitrile.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US08106190B2 |
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| Source dataset | uspto-grants-2012_01 |
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| ORD ID | ord-d07c19ef8c8e426cb13ea9882d7c3eda |
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| Source note | uspto-grants-2012_01 |
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