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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 425963Generated: October 30, 2026

Cyclohexanone → Methyl 5-chloro-2-(cyclohexylamino)benzoate

https://huagongshe.com/reaction/425963

Reaction equation

Participants

RoleNameHCIDCharge
ReactantCyclohexanoneHCID 7967—
ReactantMethyl 2-amino-5-chlorobenzoateHCID 78878—
ReactantSodium triacetoxyborohydrideHCID 5049666—
SolventHCID 22609668HCID 22609668—
ProductMethyl 5-chloro-2-(cyclohexylamino)benzoateHCID 12329834—

Reaction Steps

Cyclohexanone and sodium triacetoxyborohydride were added to a 1,2-dichloroethane-acetic acid solution of methyl 2-amino-5-chlorobenzoate, followed by stirring at room temperature. By post-treating the reaction liquid, methyl 5-chloro-2-(cyclohexylamino)benzoate was obtained.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS08106190B2
Source datasetuspto-grants-2012_01
ORD IDord-b716e0ad703b496ba1535b1168d1d4c9
Source noteuspto-grants-2012_01