HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 425966Generated: October 30, 2026
Ethylene Glycol → 4-chloro-2-{[(1S*,2S*)-2-pyrrolidin-1-ylcyclohexyl]amino}benzoic acid
https://huagongshe.com/reaction/425966
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Ethylene Glycol | HCID 174 | — |
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | Sodium Hydroxide | HCID 14798 | — |
| Reactant | 4-chloro-2-{[(1S*,2S*)-2-pyrrolidin-1-ylcyclohexyl]amino}benzonitrile | HCID 66703634 | — |
| Product | 4-chloro-2-{[(1S*,2S*)-2-pyrrolidin-1-ylcyclohexyl]amino}benzoic acid | HCID 66703737 | — |
Reaction Steps
Ethylene glycol and sodium hydroxide were added to 4-chloro-2-{[(1S*,2S*)-2-pyrrolidin-1-ylcyclohexyl]amino}benzonitrile, followed by stirring at 190° C. for 5 hours. After neutralizing the reaction liquid by adding hydrochloric acid, the organic layer was extracted with chloroform and the solvent was evaporated to obtain 4-chloro-2-{[(1S*,2S*)-2-pyrrolidin-1-ylcyclohexyl]amino}benzoic acid.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US08106190B2 |
|---|
| Source dataset | uspto-grants-2012_01 |
|---|
| ORD ID | ord-2e0c103a276e4f428f3a16ede5fcdb5b |
|---|
| Source note | uspto-grants-2012_01 |
|---|
