HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 425969Generated: October 29, 2026
Chlorosuccinimide → HCID 86634335, compound
https://huagongshe.com/reaction/425969
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Chlorosuccinimide | HCID 31398 | — |
| Reactant | HCID 86634336 | HCID 86634336 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | HCID 86634335 | HCID 86634335 | — |
Reaction Steps
1-Chloro-2,5-pyrrolidinedione (NCS) was added at room temperature to a DMF solution of tert-butyl {(1R,2R)-2-[(5-chloro-2-cyanophenyl)amino]cyclohexyl}carbamate, followed by stirring at 80° C. for 5 hours. By post-treating the reaction liquid, tert-butyl {(1R,2R)-2-[(4,5-dichloro-2-cyanophenyl)amino]cyclohexyl}carbamate was obtained.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US08106190B2 |
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| Source dataset | uspto-grants-2012_01 |
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| ORD ID | ord-dcdb03ee43b24c71b616b72b073fdb51 |
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| Source note | uspto-grants-2012_01 |
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