Hydrogen chloride-ethyl acetate → HCID 66703712, compound

HRID 425972Notes

Reaction equation

HRID 425972 reaction equation
Cl.C(OCC)(=O)C.[Cl:8][C:9]1[C:10]([CH3:28])=[CH:11][C:12]([C:26]#[N:27])=[C:13]([NH:15][C@H:16]2[CH2:21][CH2:20][CH2:19][CH2:18][C@@H:17]2[NH:22]C(=O)[O-])[CH:14]=1>C(O)C>[NH2:22][C@H:17]1[CH2:18][CH2:19][CH2:20][CH2:21][C@@H:16]1[NH:15][C:13]1[CH:14]=[C:9]([Cl:8])[C:10]([CH3:28])=[CH:11][C:12]=1[C:26]#[N:27]

Participants

4

Reactant 2

HCID 21866389Hydrogen chloride-ethyl acetateHCID 86634340HCID 86634340, compound

Product 1

HCID 66703712HCID 66703712, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

4 M Hydrogen chloride/ethyl acetate (20 ml) was added to an ethanol solution of {(1S,2S)-2-[(5-chloro-2-cyano-4-methylphenyl)amino]cyclohexyl}carbamate, followed by stirring at room temperature for 12 hours. By concentrating the reaction liquid under a reduced pressure, 2-{[(1S,2S)-2-aminocyclohexyl]amino}-4-chloro-5-methylbenzonitrile was obtained.

Workup

  1. concentrationBy concentrating
  2. customthe reaction liquid under a reduced pressure

Sources & evidence

ORD record
ord-71ad2c1784f541cb918e53bdc51dd545
Source dataset
uspto-grants-2012_01
Patent number
US08106190B2

Reaction notes

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