Acetic Acid → HCID 66703732, compound

Participants

Reaction Conditions

Reaction Steps

Under ice-cooling, sodium borohydride was slowly added in small portions to an acetic acid solution of 2-{[(1R,2R)-2-aminocyclohexyl]amino}-4-(trifluoromethyl)benzonitrile, followed by heating at 60° C. for 6 hours. By post-treating the reaction liquid, 2-{[(1R,2R)-2-(ethylamino)cyclohexyl]amino}-4-(trifluoromethyl)benzonitrile was obtained. A formalin aqueous solution and sodium triacetoxyborohydride were added to a THF solution of this, followed by stirring. By post-treating the reaction liquid, 2-({(1R,2R)-2-[ethyl(methyl)amino]cyclohexyl}amino)-4-(trifluoromethyl)benzonitrile was obtained.

Provenance & Evidence