HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 425975Generated: October 30, 2026
Thionyl Chloride → HCID 66703676, compound
https://huagongshe.com/reaction/425975
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Thionyl Chloride | HCID 24386 | — |
| Reactant | Sodium Bicarbonate | HCID 516892 | — |
| Reactant | HCID 66703818 | HCID 66703818 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | HCID 66703676 | HCID 66703676 | — |
Reaction Steps
Methanol and thionyl chloride were added to 2-{[(1S,2S)-2-aminocyclohexyl]amino}-4-(trifluoromethyl)benzonitrile, followed by stirring with heating at 60° C. After neutralizing the reaction liquid by adding sodium bicarbonate aqueous solution thereto, the reaction liquid was post-treated to obtain methyl 2-{[(1S,2S)-2-aminocyclohexyl]amino}-4-(trifluoromethyl)benzoate.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US08106190B2 |
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| Source dataset | uspto-grants-2012_01 |
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| ORD ID | ord-b68013c9a26242a9aedde4847f5f0dda |
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| Source note | uspto-grants-2012_01 |
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