HuagongsheHuagongshe Chemistry Print Report · For research reference only
ethyl 4-nitro-2-{[(1S,2S)-2-pyrrolidin-1-ylcyclohexyl]amino}benzoate → ethyl 4-amino-2-{[(1S,2S)-2-pyrrolidin-1-ylcyclohexyl]amino}benzoate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | ethyl 4-nitro-2-{[(1S,2S)-2-pyrrolidin-1-ylcyclohexyl]amino}benzoate | HCID 66703666 | — |
| Catalyst | HCID 178418390 | HCID 178418390 | — |
| Solvent | Ethanol | HCID 702 | — |
| Product | ethyl 4-amino-2-{[(1S,2S)-2-pyrrolidin-1-ylcyclohexyl]amino}benzoate | HCID 66703696 | — |
Reaction Steps
Under an atmosphere of hydrogen (1 atm) and in ethanol, catalytic hydrogenation of ethyl 4-nitro-2-{[(1S,2S)-2-pyrrolidin-1-ylcyclohexyl]amino}benzoate was carried out at room temperature in the presence of 10% palladium-carbon to obtain ethyl 4-amino-2-{[(1S,2S)-2-pyrrolidin-1-ylcyclohexyl]amino}benzoate.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08106190B2 |
| Source dataset | uspto-grants-2012_01 |
| ORD ID | ord-0e04aef2866640468442555d6e0434d0 |
| Source note | uspto-grants-2012_01 |