HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 425979Generated: October 30, 2026
Hydrochloric Acid → HCID 66703598, compound
https://huagongshe.com/reaction/425979
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | Potassium Hydroxide | HCID 14797 | — |
| Reactant | Water ethanol | HCID 19096565 | — |
| Reactant | HCID 66703713 | HCID 66703713 | — |
| Product | HCID 66703598 | HCID 66703598 | — |
Reaction Steps
Potassium hydroxide aqueous solution was added to an ethanol-water mixed solution of 2-{[(1S,2S)-2-(benzyloxy)cyclohexyl]amino}-4-(trifluoromethyl)benzonitrile. This was stirred at 100° C. for 5 hours and then spontaneously cooled. After neutralizing with 1 M hydrochloric acid, the organic layer was extracted with chloroform. By concentrating the organic layer under a reduced pressure, 2-{[(1S,2S)-2-(benzyloxy)cyclohexyl]amino}-4-(trifluoromethyl)benzoic acid was obtained.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US08106190B2 |
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| Source dataset | uspto-grants-2012_01 |
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| ORD ID | ord-3a731ed4a9934ff7860953b2d95370a5 |
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| Source note | uspto-grants-2012_01 |
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