HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 425982Generated: October 29, 2026
2-Chloronicotinic acid → HCID 66703922, compound
https://huagongshe.com/reaction/425982
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | 2-Chloronicotinic acid | HCID 76258 | — |
| Reactant | Exo-2-bornanamine | HCID 98480 | — |
| Solvent | Sodium Hydroxide | HCID 14798 | — |
| Product | HCID 66703922 | HCID 66703922 | — |
Reaction Steps
A mixture of exo-2-aminonorbornane and 2-chloronicotinic acid was stirred at 160° C. for 1 day and then spontaneously cooled. The reaction liquid was diluted with 1 M sodium hydroxide aqueous solution and then washed with diethyl ether. The water layer was neutralized with 1 M hydrochloric acid and then the precipitated crystals were collected by filtration to obtain rel-2-[(1R,2R,4S)-bicyclo[2.2.1]hept-2-ylamino]nicotinic acid.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US08106190B2 |
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| Source dataset | uspto-grants-2012_01 |
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| ORD ID | ord-65a3c2d01ca24c6ab7dcd1672e3d5a75 |
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| Source note | uspto-grants-2012_01 |
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