HuagongsheHuagongshe Chemistry Print Report · For research reference only
Cyclohexylamine → HCID 86634341, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Cyclohexylamine | HCID 7965 | — |
| Reactant | Potassium Carbonate | HCID 11430 | — |
| Reactant | Ethyl 2,6-dichloronicotinate | HCID 12263987 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | HCID 86634341 | HCID 86634341 | — |
Reaction Steps
By allowing ethyl 2,6-dichloronicotinate and cyclohexanamine to undergo the reaction at 50° C. for 1 hour in DMF in the presence of potassium carbonate, ethyl 6-chloro-2-(cyclohexylamino)nicotinate was obtained. By carrying out hydrolysis of an ethanol solution of this at 70° C. for 18 hours in the presence of 1 M sodium hydroxide, 6-chloro-2-(cyclohexylamino)nicotinic acid was obtained.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08106190B2 |
| Source dataset | uspto-grants-2012_01 |
| ORD ID | ord-224b9272228b4f01873d10be70ba34da |
| Source note | uspto-grants-2012_01 |